The Science Behind the EC System

The Science Behind the EC System

[Editor’s Note: Learn more about CBD oil and your endocannabinoid system (ES). Can you can optimize your health with CBD?]

The EC system is crucial to your health and wellness. Here’s how this important self-regulatory network works to keep you balanced, and how you can support it with CBD oil.

As you set out to learn more about cannabidiol (CBD) oil and how it naturally promotes wellness, undoubtedly you will come across a reference to the EC system.

The EC system, or endocannabinoid system, is the reason CBD oil is able to encourage balance and optimal functioning in your body.

Are you curious as to how the EC system works and its purpose? Here we dive into the science behind the EC system, and discuss how with CBD oil supplements you can support its efforts to keep you balanced.

What is the EC System?

The EC system is a major signaling network responsible for keeping a wide array of our body’s functions balanced and running at their best.

Everybody has an EC system, which works continuously to keep important functions like mood, sleep patterns, appetite, memory, metabolism, immune response, and more, balanced and running optimally.

Anytime changes in the external environment cause a function under the EC system’s watch to become imbalanced, the EC system responds by triggering a series of chemical reactions designed to bring that function back to where it should be.

As you can imagine, a well-operating EC system is crucial for reaching and maintaining health and wellness. There is even a theory referred to as endocannabinoid system deficiency that suggests that a dysfunction in the human endocannabinoid system leads to health issues. This theory, introduced in 2004 by Dr. Ethan Russo, also speculates that the EC system can be supplemented and supported by consuming a class of plant-derived diverse chemical compounds called cannabinoids.1

All mammals rely on the EC system to keep functioning running optimally, even your pets.

How Does the EC System Work?

Your EC system is made up of three components:

Together, these three mechanisms work together to monitor many of your body’s functions and make adjustments as needed whenever they become imbalanced.

Let’s say, for example, that your immune system response becomes imbalanced and begins to dysfunction. Your EC system responds by triggering the release of enzymes that synthesize cannabinoids, or endocannabinoids.

What do endocannabinoids do? Once synthesized, these body-made cannabinoids — Anandamide and 2-arachidonoylglycerol — bind to cannabinoid receptors located throughout your body. The EC system predominantly consists of two types of endocannabinoid receptors: CB1, located primarily in the brain and central nervous system, and CB2, most densely populated throughout the peripheral nervous system.

Once activated by cannabinoids, these cannabinoid receptors adjust the passage of proteins between cells, sending out signals for the body to make the adjustments necessary to get your function, in this case your immune system response, back to where it should be.

Once a function is back in balance, the EC system “turns off” the process by triggering the release of enzymes that break down cannabinoids so they no longer interact with receptors.

endocannabinoid system

How to Support the EC System

Incorporating cannabinoid products like CBD oil into your daily wellness routine can help support your EC system and its efforts to keep the body and its functions balanced.

CBD oil is a botanical extract made from high-CBD, low-THC hemp. CBD, short for cannabidiol, is one of over 100 plant-derived cannabinoids (phytocannabinoids) presently identified in cannabis plants. In hemp, CBD dominates the plant’s makeup.

Just like body-synthesized endocannabinoids, plant-derived cannabinoids like CBD interact with your EC system’s cannabinoid receptors. Through its interaction with cannabinoid receptors, CBD stimulates the EC system, encouraging the regulatory system to more efficiently keep functions level.

As you read more about the endocannabinoid system and CBD, you’ll discover that CBD doesn’t directly activate the EC system’s CB1 or CB2 receptors. Instead, CBD interacts indirectly with them and works to suppress the CB1 and CB2 activating qualities of other cannabinoids.

Most people do very little to support the health of the EC system, because cannabinoids have not been part of the average diet for decades. Regularly taking CBD oil products as dietary supplements can augment the body’s own cannabinoids for a more well-operating EC system.

While derived from cannabis, CBD is not intoxicating. This means it will not cause any temporary euphoric effects like THC, or tetrahydrocannabinol, a cannabinoid associated with medical marijuana.

Hemp naturally contains no more than 0.3 percent THC by dry weight. As such, CBD oil derived from hemp contains only trace levels of THC, far less than the amount needed for intoxicating, or a “high.” Supporting the EC system with CBD oil has been found to be safe with no serious adverse side effects. This is particularly beneficial for anyone interested in the natural balancing properties of cannabinoids yet want to avoid intoxicating effects.

Once extracted from hemp, pure CBD oil can be taken on its own or infused into various types of products, including CBD tinctures, CBD capsules, CBD vape oil, CBD topicals and body care products, and more. It can also be refined to create concentrated products like CBD isolate. There are even CBD products for pets.
cbd oil tincture

Myths Surrounding the EC System

With all the contradictory and confusing writings out there about the EC system, it can be hard to determine what is truth and what is misinformation.

There are several misconceptions about the EC system that regularly pop up if you search, “What is the EC system?” Here we address the four most common EC system-related myths to help clarify any confusion you have about the EC system and how it works.

Myth #1: The EC system emerged in the human body because of cannabis use.

Scientists did first discover the EC system by retracing the metabolic pathway of cannabis-derived cannabinoids. However, the EC system did not emerge in the human body because of the use of cannabis and absorption of its cannabinoids. The EC system was already in place, allowing cannabinoids like CBD to interact with the system and encourage its performance.

Myth #2: CB1 receptors are only in the brain and central nervous system, while CB2 receptors are only in the peripheral nervous system.

While it’s true that CB1 and CB2 receptors are most heavily concentrated in these areas of the body, both types of receptors are more widely distributed and found on cells all throughout the body.

Myth #3: THC binds to CB1 receptors and CBD binds to CB2 receptors.

Like all cannabinoids, THC and CBD both interact with the EC system and its specialized cannabinoid receptors, CB1 and CB2. However, while THC directly binds with both CB1 and CB2 receptors, CBD has little affinity for the two receptors and doesn’t bind to either. Instead, it acts as an indirect antagonist and suppresses the receptors’ abilities to be activated by other compounds.

Myth #4: Cannabinoids are only found in cannabis plants.

Cannabinoids and cannabinoid-like substances that interact with the EC system are actually found in many plants. Outside of hemp and marijuana, cannabinoids are found in Echinacea, electric daisy, helichrysum umbraculigerum, liverwort, black pepper, cacao, black truffles, and more.
hemp ec system

More About the EC System and CBD

There have been thousands of studies done on cannabinoids and their potential benefits. Learn even more about the EC system and how its efforts can be supported through the use of CBD oil products by visiting our CBD Oil Education page.

References:

  1. Russo, E.B. (2004, Feb-Apr). Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions? Neuro Endocrinology Letters, 25(1-2), 31-9.

The Science Behind the EC System was posted on medical marijuana inc.

Understanding the Many Medical Marijuana Uses

Understanding the Many Medical Marijuana Uses

[Editor’s Note: Well researched article on the conditions medical cannabis helps. Great cannabis research reference tool. There are a lot of great references at the end.]

Medical marijuana is now widely used as a substitute or supplement to traditional prescription drugs. Here you can learn about medical marijuana’s many uses.

The use of marijuana for medicinal purposes dates back centuries. From its earliest known use in Ancient China to today, our awareness of potential medical marijuana uses has grown.

In the United States, cannabis was widely utilized as a patented medicine during the 19th and early 20th centuries. It’s been only in the last few decades, however, that researchers and medical experts started to truly understand medical marijuana benefits.

With that growing acknowledgement of cannabis and its therapeutic effects, attitudes toward the substance have shifted dramatically. This has led a significant expansion in legal access throughout the United States and the globe.

Keep reading to learn more about the wide array of medical marijuana uses, and the science behind cannabis’ therapeutic potential.

What is Medical Marijuana?

Medical marijuana refers to using the cannabis plant or its extracts to treat symptoms of an illness or a disease.

Cannabis contains more than 400 chemical compounds that when absorbed interact with the body’s systems. Many of these compounds, particularly a type of active chemical compound called cannabinoids, have shown to have medicinal properties beneficial for treating or managing various ailments.

The U.S. Food and Drug Administration (FDA) has yet to recognize or approve marijuana as a food or medicine, but the agency has approved some cannabis-based medications for use in the U.S.

Many state lawmakers and voters recognize the various medical marijuana benefits. More than 60 percent of states and territories in the U.S. have legalized medical marijuana. Each state has their own regulations on medical marijuana uses, with many requiring that patients be first diagnosed with particular qualifying conditions.
medical cannabis

Medical Marijuana Uses

People have used marijuana to address health conditions for at least 3,000 years, and throughout history many civilizations have documented their medical marijuana uses.

Cannabis also has a long history in America, and prior to prohibition was considered a viable treatment option in the U.S. Pharmacopeia. Over the past 25 years, the medical use of marijuana has started to return and today there are thought to be roughly 3.5 million medical marijuana users in the U.S.

In the world of medical marijuana uses, there is still a lot to discover about medical marijuana benefits. Researchers are regularly seeking to learn more about cannabis and its potential for improving symptoms, treating ailments, and enhancing the quality of life among those diagnosed with an illness or disease.

By far the most common question from those interested in cannabis and its therapeutic potential is: What is medical marijuana used for?

Today there are over 50 different conditions or symptoms that are legally treatable with medical marijuana. Medical cannabis has the potential to systematically replace multi-billion dollar medication industries around the world, according to a pair of recent studies.

Here we summarize various medical marijuana uses, exploring why people use medical marijuana and how it benefits them.

Pain Management

By far the most common reason people use medical marijuana is for pain management. Chronic and severe pain accounts for nearly two-thirds of all medical cannabis patients in the U.S.

The benefits of medical marijuana for pain have been widely studied, with research showing that cannabis is effective for reducing both neuropathic and nociceptive pain. Even refractory pain situations, where the discomfort is resistant to other traditional medications, have shown to be treatable with medical marijuana.3,7,11

A survey completed only a few years ago found that medical marijuana treatments elicited a 64 percent drop in average pain.12 Cannabis has even showed potential for replacing or substituting prescription opioids, with more than 9 of 10 pain patients preferring cannabis over opioid and non-opioid medications.

Nearly all of the states that allow medicinal cannabis acknowledge the benefits of medical marijuana for pain and include it as a qualifying condition.

Slow the Progression of Alzheimer’s and Parkinson’s Diseases

For the estimated 5.7 million Americans living with Alzheimer’s disease and the approximately 60,000 Americans diagnosed with Parkinson’s disease each year, medical marijuana can help manage symptoms and may even help slow the disease’s progression.

Among Alzheimer’s disease patients, medical marijuana has shown to cause a significant reduction in behavioral and psychological symptoms, including agitation, aggression, irritability, apathy, delusions, and sleep problems.

Medical marijuana can also effectively reduce the motor-related symptoms of Parkinson’s disease, including tremors. By binding with dopamine receptors, cannabis-derived cannabinoids reduce the effects of disease-related drops in dopamine that result in loss of motor control.

Cannabinoid effects on the body also appear to trigger neuroprotective and anti-inflammatory responses, which can slow the progression of both neurodegenerative disorders.

Reduce the Debilitating Seizures Caused by Epilepsy

Epilepsy affects an estimated 3.4 million people nationwide, and medical marijuana can be used to reduce the number and severity of seizures in both adults and children.

The influence of cannabis-derived cannabinoids on one of the body’s major self-regulatory networks appears to modulate seizure activity by reducing overall neuronal excitability and inhibiting the release of a particular neurotransmitter.2 Recently, researchers found that cannabis reduced seizures in 90 percent of adults and 71 percent of children.

Kill or Limit the Growth of Cancer Cells

For the estimated 1.7 million people in the U.S. who will be diagnosed with cancer this year, medical marijuana benefits by helping manage the symptoms associated with chemotherapy and may even combat cancer cells themselves.

Medical marijuana is commonly recommended by doctors to cancer patients to help curtail the nausea, pain, and weight loss that often come about following cancer treatments. Studies also indicate that cannabinoid effects stimulate a series of chemical reactions that can, in some cases, suppress tumor growth.10

Reduce Spasms Associated with Multiple Sclerosis (MS)

For the estimated 400,000 people in the U.S. with MS, medical marijuana can help reduce the pain, muscle stiffness, and spams often caused by the disease.1,5

Research also suggests that medical marijuana may be able to slow the progression of MS by helping modulate the inflammatory reaction and assisting in neuroregeneration.4,8

Lessen the Emotional Impact and Reduce Anxiety Caused by Post-Traumatic Stress Disorder (PTSD)

Approximately 24.4 million people in the U.S. have PTSD at any given time. Medical marijuana can help PTSD patients manage anxiety, fear, and sleep problems after experiencing a traumatic event.

By modulating the release of a neurotransmitter, cannabis-derived cannabinoids can help block fear memory formation and help regulate the stress response.9

Other Medical Marijuana Uses

Outside of these conditions, there are many other medical marijuana uses. Doctors commonly recommend medical marijuana to:

  • Manage anxiety
  • Control symptoms related to attention deficit hyperactivity disorder (ADHD)
  • Decrease intraocular pressure in the eye to help treat glaucoma
  • Reduce the frequency and severity of nausea
  • Manage symptoms and slow the progression of Amyotrophic Lateral Sclerosis (ALS)
  • Promote behavior and communication in patients with autism
  • Lower pain and improve sleep in those with fibromyalgia
  • Reduce the side effects caused by HIV/AIDS treatments
  • Reduce migraine-related pain
  • Facilitate recovery following a traumatic brain injury (TBI)

The National Academies of Sciences, Engineering, and Medicine in 2017 published a study investigating medical marijuana uses. The rigorous and weighty 395-page report summarized research-backed medical marijuana benefits and recommended that more studied needed to be done to more thoroughly understand cannabinoid effects.

Even more medical marijuana uses are available to explore on our education page.
medical marijuana doctor

Cannabinoids Effects

So exactly how does medical marijuana work? Exploring medical marijuana uses is incomplete without an explanation of cannabis-derived cannabinoids and their effects.

The medical benefits of weed are directly related to the 100-plus cannabinoids found in cannabis, some of which have been found to have therapeutically beneficial properties. Once absorbed, these active chemical compounds alter the release of neurotransmitters in the brain by acting on cannabinoid receptors, eliciting various effects.

Cannabinoid receptors are located on cells throughout the body. They are a crucial component of the endocannabinoid system, or ECS, one of the body’s largest self-regulatory networks. The ECS is responsible for keeping a wide array of functions in balance.

While scientists only discovered cannabinoids decades ago, thousands of studies have been already completed on cannabinoids effects, and new studies on medical marijuana benefits are regularly being published.

The body produces its own cannabinoid chemicals, called endocannabinoids. Through their interaction with cannabinoid receptors, these chemicals play a role in regulating memory, concentration, mood, appetite, sleep habits, immune system response, pain sensation, and more.

Many mental and physical health issues are thought to result from the dysregulation of the body’s EC system, which could be due to a lack of cannabinoids or cannabinoid receptors.

Cannabis-derived cannabinoids can serve to supplement the body’s own endocannabinoids, stimulating the endocannabinoid system so that it more effectively keeps functions balanced and running optimally. In other words, cannabinoids effects may help the body’s own natural chemicals work better.

As the research findings above suggest, these health benefits of cannabinoids can help treat symptoms of illness and other conditions. Many of the medicinal benefits of marijuana have to do with it encouraging a well operating ECS.

Using Medical Marijuana

When it comes to medical marijuana uses, patients have several methods to choose from.

Medical marijuana may be:

  • Vaped or dabbed: Heating up marijuana to its respective boiling point with a vaporizer to release cannabinoids and other active ingredients as an inhalable vapor.
  • Smoked: Setting fire to marijuana in the form of a hand-rolled joint, pipe, or water pipe (bong) to release cannabinoids as an inhalable smoke.
  • Eaten: Swallowing marijuana in the form of an edible, such as a cookie, gummy, or beverage.
  • Taken under the tongue: Placing liquid-form marijuana under the tongue for 60-90 seconds and allowing it to absorb through the mucous membranes of the mouth.
  • Applied topically: Applying cannabis-infused body products like balms, salves, lotions, and oils, directly onto the skin for targeted effects.

vaping medical marijuana

Is Marijuana Legal?

Medical marijuana is only legally available to patients in U.S. states and territories that have established medical marijuana programs.

Thankfully, today a majority of Americans live in a state where marijuana can be used as medicine. While marijuana in all forms remains continues to be illegal at the federal level, 32 states and Washington, D.C. and Puerto Rico have passed their own laws permitting its use.

After asking, “Is marijuana legal where I live?” and discovering you live in a medical marijuana state, the next step is to look into your state’s particular regulations.

Medical marijuana laws vary widely state by state, sometimes even from city to city. The variations include the forms of marijuana legally available, the percentage of tetrahydrocannabinol (THC) allowed, and conditions that qualify patients for a state-issued medical marijuana card.

Some states allow for registered medical marijuana patients to buy cannabis from licensed dispensaries and cultivate their own cannabis plants at home. Others allow patients to purchase cannabis through dispensaries, but not partake in home cultivation. A few only allow home cultivation.

More Americans than ever now believe there are viable reasons why medical marijuana should be legal under federal law. With a growing body of research revealing the benefits of medical marijuana uses of the cannabis plant to treat conditions, diseases, and symptoms, 94 percent of Americans are now in favor of legal medical marijuana.

To find out what’s allowed in your state, check out our Overview of U.S. Medical Marijuana Law or visit our education page and scroll to find your state. We also provide tips on how to discuss medical marijuana with your doctor and getting a medical marijuana card.

More on Medical Marijuana

There is always more to learn about potential medical marijuana uses and the benefits of cannabinoids effects through our education page. There, you’ll find an overview of cannabis research findings and more about the medical uses of weed.

 

References:

  1. Baker, D., Pryce, G., Croxford, J.L., Brown, P., Pertwee, R.G., Huffman, J.W., and Layward, L. (2000, March 2). Cannabinoids control spasticity and tremor in a multiple sclerosis model. Nature, 404(6773), 84-7. Retrieved from http://www.nature.com/nature/journal/v404/n6773/full/404084a0.html.
  2. Blair, R.E., Deshpande, L.S., Sombati, S., Falenski, K.W., Martin, B.R., and DeLorenzo, R.J. (2006, June). Activation of the cannabinoid type-1 receptor mediates the anticonvulsant properties of cannabinoids in the hippocampal neuronal culture models of acquired epilepsy and status epilepticus. The Journal of Pharmacology and Experimental Therapeutics, 317(3), 1072-1078. Retrieved from http://jpet.aspetjournals.org/content/317/3/1072.long.
  3. Boychuck, D.G., Goddard, G., Mauro, G., and Orellana, M.F. (2015 Winter). The effectiveness of cannabinoids in the management of chronic nonmalignant neuropathic pain: a systematic review. Journal of Oral & Facial Pain and Headache, 29(1), 7-14.
  4. Croxford, J.L., Pryce, G., Jackson, S.J., Ledent, C., Giovannoni, G., Pertwee, R.G., Yamamura, T., and Baker, D. (2008, January). Cannabinoid-mediated neuroprotection, not immunosuppression, may be more relevant to multiple sclerosis. Journal of Neuroimmunology, 193(1-2), 120-9. Retrieved from http://www.jni-journal.com/article/S0165-5728(07)00396-7/fulltext.
  5. Fox, P., Bain, P.G., Glickman, S., Carroll, C., and Zajicek, J. (2004, April). The effect of cannabis on tremor in patients with multiple sclerosis. Neurology, 62(7), 1105-9. Retrieved from http://www.neurology.org/content/62/7/1105.long.
  6. Kubajewska, I., and Constantinescu, C.S. (2010, August). Cannabinoids and experimental models of multiple sclerosis. Immunobiology, 215(8), 647-57. Retrieved from http://www.sciencedirect.com/science/article/pii/S0171298509001442.
  7. Lynch, M.E., and Campbell, F. (2011, November). Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials. British Journal of Clinical Pharmacology, 72(5), 735-744.
  8. Pavisian, B., MacIntosh, B.J., Szilagyi, G., Staines, R.W., O’Connor, P., Feinstein, A. (2014, May 27). Effects of cannabis on cognition in patients with MS: a psychometric and MRI study. Neurology, 82(21), 1879-87. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105254/.
  9. Potter, C.M., Vujanovic, A.A., Marshall-Verenz, E.C., Bernstein, A., and Bonn-Miller, M.O. (2011, April). Posttraumatic stress and marijuana use coping motives: the mediating role of distress tolerance. Journal of Anxiety Disorders, 25(3), 437-43. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101637/.
  10. Preet, A., Ganju, R.K.., and Groopman, J.E. (2008, January). Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo. Oncogene, 27(3), 339-46. Retrieved from http://www.nature.com/onc/journal/v27/n3/full/1210641a.html.
  11. Wallace, M.S., Marcotte, T.D., Umlauf, A., Gouaux, B., and Atkinson, J.H. (2015, July). Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy. Journal of Pain, 16(7), 616-27.
  12. Webb, C. W., & Webb, S. M. (2014). Therapeutic Benefits of Cannabis: A Patient Survey. Hawai’i Journal of Medicine & Public Health, 73(4), 109–111. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998228/.

Understanding the Many Medical Marijuana Uses was posted on medical marijuana inc.

10 of the Most Unique CBD Facts You Probably Never Knew

10 of the Most Unique CBD Facts You Probably Never Knew

[Editor’s Note: If you’ve been curious about CBD facts, this article will help sort out face from fiction.]

CBD is a fascinating phytocannabinoid with many qualities. Here we reveal 10 super unique CBD facts you may be surprised to learn about.

It seems that CBD is everywhere you look these days. Media and news outlets have caught the CBD wave, and have helped spread the word about the all-natural cannabinoid and its benefits.

Still, there is probably so much that you don’t know about CBD, even with all the CBD facts that are out there.

Cannabis has a long history, but only over the last decade or so has CBD oil surged in popularity as a dietary supplement to promote wellness. CBD, or cannabidiol, is an all-natural cannabinoid found in cannabis that supports one of the body’s largest self-regulatory systems.

Looking to learn more about CBD? Here, we reveal the top 10 most unique CBD facts.

1. CBD Can Come From Both Hemp and Marijuana

With so much misinformation on the internet about CBD, a common misconception is that CBD only comes from one type of cannabis plant. In reality, CBD is found throughout the stalks, flowers, stems, leaves and seeds of both hemp and marijuana.

Yes, hemp and marijuana can be sources of CBD. However, marijuana is naturally lower in CBD than THC, or tetrahydrocannabinol, the intoxicating compound known for its euphoric properties. In hemp, CBD dominates the plant’s makeup.

What does this CBD fact mean? Hemp’s naturally higher levels of CBD make it an ideal source for CBD extract products like CBD oil. Hemp cultivars also grow much faster than marijuana, allowing farmers to plant multiple hemp crops a season for a more environmentally sustainable and conscious CBD product.

With that said, there are thousands of unique varieties of hemp, and not all contain the same percentages of CBD. The cultivars used to create CBD oil, in general, contain significantly higher concentrations of CBD than others.

2. CBD is One of Over 100 Cannabis-Derived Cannabinoids

CBD rightfully garners much of the attention in the cannabis industry due to its natural benefits. But, did you know that it is just one of more than 100 cannabinoids scientists have so far discovered?

Along with THC, CBD is the most prominent of the many cannabinoids found in cannabis. Outside of these two well-researched compounds, however, are dozens more present at low levels. Like CBD, these cannabinoids interact with the body’s native system and elicit various natural effects.

Some of the more well-known cannabis-derived cannabinoids, or phytocannabinoids, that are found in cannabis plants include cannabichromene (CBC), cannabinol (CBN), cannabigerol (CBG), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), delta-8-tetrahydrocannabinol (Δ8-THC), cannabidiolic acid (CBDA), and tetrahydrocannabinolic acid (THCA).

While researchers have identified many cannabinoids, they have primarily focused their efforts on studying and understanding how CBD and THC influence the body’s systems. Many studies have explored CBD oil effects and CBD oil benefits, as scientists look to learn more about potential CBD hemp oil uses.

3. Cannabis Growers Can Breed High-CBD Plants

Not all cannabis contains the same amount of cannabidiol. There are now thousands of unique cannabis strains available to consumers. On a chemical level, these strains differ in their make-up of their cannabinoid content, providing various CBD concentration options.

Thanks to crossbreeding cannabis growers are able to cultivate cannabis plants that contain high levels of CBD.

These high-CBD strains, also referred to as CBD-rich strains, have become a popular choice for anyone interested in the natural effects of cannabinoids while maintaining a clear head.

Here’s a fun CBD fact: When Medical Marijuana, Inc. was searching for the perfect cannabis seed to introduce CBD oil products to the market, our experts first tested a total of 3,000 possible varieties to find the perfect hemp cultivar that contained the optimum level of cannabidiol.

4. CBD Actually Is “Psychoactive”

CBD is regularly classified as a “non-psychoactive” compound nearly everywhere it is mentioned.

What people mean when they describe CBD in such a way is that it doesn’t elicit any temporary euphoric effects. This CBD fact is true: CBD is non-intoxicating and has shown to have no serious side effects, which is why many feel comfortable to buy CBD oil for all of their family members, including children and seniors.

While it is correct to say that CBD won’t cause a “high,” it is incorrect to describe it non-psychoactive. The term “non-psychoactive” means that a substance does not affect the mind, which isn’t an accurate description of CBD.

Dr. Ethan Russo, a respected long-time cannabinoid researcher, recently made the argument that, “CBD is frequently mischaracterized in lay, electronic, and scientific sources as ‘non-psychoactive’ or ‘non-psychotropic’ in comparison to THC” due to what research has found about the compound’s natural effects.2

The true cannabidiol fact is that CBD has demonstrated that it influences one of the body’s major native regulatory networks, the endocannabinoid system. CBD’s interaction with the endocannabinoid system does alter the release of neurotransmitters in the brain and elsewhere. In doing so, CBD encourages balance in the body and its functions.

Russo went on to explain: “More accurately, CBD should be preferably labeled as ‘non-intoxicating,’ and lacking associated reinforcement, craving, compulsive use, etc., that would indicate a significant drug abuse liability.”

This is one of the most important CBD facts you learn today: While CBD is non-intoxicating and won’t cause impairment, it is psychoactive.
cbd oil facts

5. CBD is CBD, No Matter the Source

No matter where it comes from, CBD is CBD. Some cannabinoid users mistakenly think that CBD from marijuana is somehow more potent than CBD derived from hemp. On a molecular level, CBD from hemp is the same as CBD from marijuana.

Researcher Franjo Grotenhermen of the International Association for Cannabinoid Medicines has been quoted saying, “CBD is CBD. The human body does not care where the molecule comes from.”

An easy way to understand this CBD fact is to consider vitamin C. No matter whether your body absorbs it through an orange or a lemon, it will treat and use the water-soluble vitamin the same way.

While it is true that the percentage of CBD in hemp plants by dry weight is generally lower than the percentage of CBD in some specially bred marijuana plants, once CBD oil is extracted from the plant, this difference becomes negligible.

6. CBD May Help You Manage a Cannabinoid Deficiency

A relatively new theory from Dr. Russo, mentioned earlier, speculates that supplementing the body with plant-based cannabinoids like CBD could possibly be beneficial for addressing the nutritional deficiency.

This theory, called the clinical endocannabinoid deficiency syndrome (CECD), attempts to explain why in some cases the endocannabinoid system is unable to properly keep the body balanced. It proposes that a deficiency in cannabinoids can lead to a dysfunction in the endocannabinoid system, leading to health issues.1

Americans may be at a greater risk for being depleted of cannabinoids since cannabis, both marijuana and hemp, were prohibited in the 1930’s. Eliminating hemp from the diet may have contributed to cannabinoid deficiency issues.

Adding CBD oil to your diet could, the theory suggests, augment the body’s own cannabinoids and help the endocannabinoid system effectively balance the body.

7. CBD’s Benefits Can Be Maximized with Hemp’s Other Phytochemicals

Of all the CBD facts, this one may surprise you the most. Taking CBD with all the other natural compounds found in cannabis may enhance the compound’s effects.

The entourage effect, first introduced in 1998 by renowned researchers Raphael Mechoulam and S. Ben-Shabat, suggests that the sum total of all the chemical compounds in cannabis — including CBD and the other hundreds of plant compounds — act synergistically to provide a more powerful effect.

In other words, these scientists and others believe that consuming full-spectrum CBD oil offers greater natural wellness properties than taking isolated CBD compounds alone.

Hemp contains more than just CBD. It is made up of 400-plus active compounds, including cannabinoids, flavonoids, and terpenes, as well as essential vitamins and minerals, fatty acids, fiber, protein, and chlorophyll.

While CBD on its own has demonstrated undeniable natural benefits, the entourage effect could mean that the compound’s benefits can be maximized when consumed with the other natural compounds found in cannabis.

8. CBD is Beneficial, Even if You’re Healthy

Many people first incorporate CBD into their lives once facing health problems, but CBD offers botanical properties that are beneficial for anyone interested in promoting wellness.

CBD’s stimulation and support of the endocannabinoid system may help it continue to run efficiently.

Hemp-derived CBD oil also supports the maintenance of a complete and healthy diet. When discussing CBD oil facts, it’s impossible to not mention that in addition to CBD and other trace cannabinoids, CBD oil is also a natural source of many vitamins and minerals, including B complex vitamins, vitamin C, vitamin E, calcium, and magnesium. CBD oil also contains protein, fatty acids, and other dietary nutrients critical for keeping your body running at its best.

For healthy people, supplementing the endocannabinoid system, the largest self-regulatory system, with plant-based cannabinoids like CBD is a potential way to maintain optimal health. The balancing effects of CBD combined with the nutritional content of hemp oil will help ensure your body is given what it needs for peak performance each day.

9. CBD Can Also Be Beneficial for Your Pet

Like us, many of our loved pets can benefit from the natural balancing properties of CBD. All mammals, including dogs, cats, horses, and more, have an endocannabinoid system, the bodily system with which cannabinoids interact.

A growing number of pet owners are discovering how adding CBD oil to their pets’ diets can be a natural alternative to promote well-being in their pets.

CBD’s support of the endocannabinoid system has shown to promote pets’ cardiovascular function, support healthy joints, and promote neurological health and emotional behavior. Also, for many pet owners, hemp CBD oil’s nutritional profile compliments the dietary requirements of their animal.

Today, you can buy CBD oil products specifically designed for pets, including CBD oils, CBD liquids, and CBD treats.

10. CBD is Federally Legal, Provided it Comes From Hemp

CBD, provided it is derived from hemp, is federally legal in the United States. While a Ninth Circuit Court of Appeals ruling had allowed hemp CBD manufacturers to operate for years without interference, the passing of the 2018 Farm Bill in late December eliminated any confusion of hemp CBD’s legal status.

The hemp provision in the new Farm Bill allows hemp to be legally “cultivated for any use,” including the production and extraction of CBD. It also means that you can legally use and buy CBD oil, without a doctor’s recommendation or prescription.

For those curious about cannabinoids and CBD oil facts, this is a big deal. While states can regulate hemp and hemp CBD as they choose, the new federal law will make many consumers familiar with CBD oil benefits more willing to try the variety of CBD oil products that are available to buy. Nearly everyone in the country can legally shop for CBD oil products and have their order delivered right to their doorstep.
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Learn Even More About CBD

There is always more to learn about cannabidiol (CBD) and how it can help the endocannabinoid system regulate the body’s homeostasis. Learn more cannabidiol facts through our education page.

To start incorporating the natural wellness benefits of CBD oil products into your routine, visit the Medical Marijuana, Inc. online shop today.

 

References:

  1. Russo, E.B. (2004, Feb-Apr). Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions? Neuro Endocrinology Letters, 25(1-2), 31-9.
  2. Russo, E.B. (2017, March). Cannabidiol claims and misconceptions. Trends in Pharmacological Sciences, 38(3), 198-201.

10 of the Most Unique CBD Facts You Probably Never Knew was posted on medical marijuana inc.

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