Original Post: High Times: How Long Does a Weed High Last? The Definitive Guide
[Canniseur: Interesting question with a lot of variables. Maybe too many to be definitive. There is such a thing as too much cannabis, but the reaction is usually paranoia or anxiety. Nobody has ever died from too much cannabis. But you can feel pretty miserable for a few hours. You can find out here parts of the very slippery equation how long does the buzz last.]
How long does a marijuana high last? What if it’s from an edible? Or a vape? We answer all of your questions. Check out the definitive guide on High Times.
Why Worry How Long Your Weed High Will Last?
Maybe things aren’t as dire as I’m imagining. Maybe you need to get behind the wheel eventually and want to know how long you should wait to drive. Perhaps you just want to know what kind of experience to expect from different cannabis products and delivery methods.
Perhaps you’re thinking strategically: that awesome band goes on at 10 p.m. and you want to plan your session before they hit, so you peak when they rock your favorite track. Or maybe you’re a medical patient who wants to leave space in the day for your treatment without compromising your productivity.
After all, there are all kinds of reasons you might be asking yourself “how long does a marijuana high last?” If you have some experience with weed, you probably already have a sense of how long your high sticks around. But you might still want to know how you can take control over that aspect of your experience.
And if you’re relatively new to cannabis, having an authoritative answer is an important part of making sure you have an enjoyable session. For everyone who enjoys cannabis, timing, as they say, is everything.
How Long Does A High Last? Use the “Highness Equation” to Find Out
It might not get past the peer review board of a medical journal, but here’s a more-or-less scientific way to “calculate” how long you can expect your weed high to last. Call it the “highness equation.”
The highness equation incorporates the four major aspects that determine how long your marijuana high will last. Here it is:
Length of High = ( (dose x concentration) / (metabolism x tolerance) ) x delivery method
So that’s the dose you take multiplied by the concentration of the product, divided by your metabolism times your tolerance, all multiplied by the delivery method factor: ingestion or inhalation.
In other words: how much weed you put in your body, divided by how your body processes and responds, all shaped by the specific path the weed takes through your system.
It’s less complicated than it sounds. And if you’re looking for a bottom line answer—the median, the average, the “ballpark,” then your answer is simple.
After you get high from inhaling weed, expect to stay high for about one to two hours. If you’ve eaten your cannabis, your high will last about 3 to 4 hours, maybe longer.
But if the tl;dr version doesn’t satisfy, read on to find out the factors that influence how long your high lasts. Then, once you figure out where you fall, you can start experimenting with ways to prolong, or if need be, shorten your high.
William Casey/ Shutterstock
Your High Lasts As Long As THC Meets Up With Your Endocannabinoid System
But that doesn’t mean you necessarily feel high. And there’s the crux of the question. Your “high” is the sum of an infinitely complex series of metabolic and chemical reactions occurring all throughout your body.
Whether we perceive the effects of those reactions depends on their intensity and our sensitivity to them. And that’s why you’ll find studies claiming that the effects of cannabis can last from 5 hours up to a full day.
That may be true on a chemical level. But THC can interact with our bodies without giving us the experience of feeling high, especially at low levels.
And that’s where the bottom of our “highness equation” comes in: metabolism x tolerance. Being on the bottom of the equation means these are the factors that work against your high, shortening how long you feel the effects of THC.
Metabolism x Tolerance
There’s a common misconception that a person’s weight determines how high they get and how long that high will last. But in fact, it’s a person’s metabolism that plays a major role in the length of a high.
The length of your high depends on the presence of THC in your bloodstream. Your blood carries that THC to the network of cell receptors it binds to, the endocannabinoid system (ECS).
Your body is also in the business of metabolizing the stuff you put into it, breaking it down, taking what it needs, and expelling the rest.
So if you’ve got a high metabolism, your highs will tend to be shorter. Or at least, your body is working against the clock a little bit.
Then, there’s that elusive and hard-to-quantify factor of tolerance. In common parlance, we say we have a high or low tolerance to weed. But in reality, what we mean is that we have a higher or lower tolerance to the dopamine and other neurotransmitters our brain releases when THC meets up with the ECS.
The good news is, cannabis doesn’t so thoroughly deplete our dopamine supplies that we have to chase ever larger quantities to get the same effect.
But that also means THC’s powers are limited. Hence the ceiling effect frequent users experience, where no matter what they do, they can’t get higher than a certain point. If you’re hitting that ceiling, the answer to the question “how long does a high last?” is probably not long enough.
For most regular cannabis users, however, the same dose will produce roughly the same experience time after time. For heavy users, even a short “tolerance break” can restore your tolerance levels to their low defaults, making your next high feel more like your first.
However, if you’ve built up a tolerance over time or with frequent use, your high is going to feel shorter for sure.
If You Want a Longer High, Consider Upping Your Dosage or Using Higher-Potency Products
Now that we’ve covered what shortens the length of your high, let’s look at what extends it. This is definitely the simpler part of the equation.
Put more weed into your system, and in all likelihood, you’re going to have a longer high. That means smoking strains with higher THC concentrations. Or vaping concentrates—or even better distillates, with upwards of 85 percent THC.
It also means taking a larger dose. Not only will your high last longer, it will stretch out your peak so you enjoy your high as long as your body allows. How long does a high last for you if you smoke flower versus vape concentrates?
How Long Does A High Last: Calculating Dose x Concentration
The top of our highness equation is pretty self-explanatory. But a few points bear repeating.
If you’re new to cannabis, it’s really a good idea to start with smaller doses. Don’t feel like you have to take huge rips or smoke multiple bowls just because the other kids are doing it. If you want that, you’ll get there in due time.
For now, appreciate what you have, that veteran weed enthusiasts often sorely miss: those early, heady days when a single puff sent you to outer space. (Maybe that’s part of what drives dabbing culture: that desire to recreate those first encounters with weed—that inimitable intensity and euphoria.)
The rest of us are busy chasing that dragon with ever-higher concentrations and tech that makes huge doses possible. Rip a 2-gram dab in one sitting and you’ll be high for the better part of the day, probably. Rip 20 grams and you’ll probably feel high for the rest of the week.
So when it comes to dosage, that’s easy. Smoke or vape more for a longer high. Even better, spread out your sessions. That will keep tossing you back up to the peak of your high when you’re on your way down.
And in terms of concentration, look for high-THC strains and strains with ultra-low CBD. (CBD can counterbalance the effects of THC on your system, shortening your high.) Or just stick with concentrates and extracts.
Canna Obscura/ Shutterstock
The Delivery Method Factor: Inhale or Eat?
We’ve covered all the parts of the highness equation. Except for the one that shapes them all: delivery method.
Those who’ve tried them know that edibles tend to produce a much longer-lasting high than inhalation methods.
That’s because of the metabolic pathway that THC takes through your body when you eat it versus when you inhale it. To make a long story short, your digestive tract converts THC into a different active form than heating alone.
How long does a high last from consuming edibles? Well that form, THC-COOH, or carboxy-THC, has some serious staying power. But your body takes some time to produce it. That’s why you have to wait 45 minutes to an hour or so for an edible to really kick in.
Once that THC-COOH is pumping through your bloodstream, you’re along for the ride until your body is finished processing it. Again, that can be about three to four hours on average and sometimes longer.
So for those truly looking for an extended high experience and who have the patience for an edible or drinkable cannabis product to kick in, ingesting your weed is the way to go.
How Long Does A Weed High Last For You? Your Mileage May Vary
How long does a weed high last if you eat your cannabis? How long does a marijuana high last if you smoke flower? Just generally, how long does a high last? If you’ve come away with anything from this article, hopefully it’s an appreciation for the complex chemical dance that is a weed high, and all the factors that make up the answer to those questions.
Of course, there’s no definite, constant answer. The lengths of your own highs will change. No need to compare them to other folks’.
So, how long does a high last for you? If you plan on one to two hours for inhaled cannabis and three to four with ingested weed, longer with higher doses and concentrations and shorter with higher metabolisms and tolerances, you’ll be all set.
[Updated from a post originally published in July, 2018]
How Long Does a Weed High Last? The Definitive Guide was posted on High Times.
Original Post: High Times: Researchers At Miami University Produce Psilocybin From E. coli Bacteria
[Canniseur: E. Coli are a common bacteria in the gut of anyone who is reading this, even though it’s portrayed in the news as bad bacteria. That’s a different strain from the strain naturally occurring in our bodies. E.Coli helps turn food you’ve eaten into waste material. Somehow it’s ironic that we could manufacture our own hallucinogens in our own bodies. Nobody would have to know.]
With a copy/paste of some mushroom DNA, researchers have genetically engineered E. coli to mass produce psilocybin.
Forget going through the trouble of growing mushrooms. Researchers at Miami University in Oxford, Ohio have figured out a way to mass produce psilocybin using bacteria. And they say they’re yielding quantities of the therapeutic compound that would otherwise require some serious square footage, not to mention many months, to yield from mushrooms. But this isn’t a synthetic or artificial process. Instead, the team of researchers—undergraduates led by assistant professor Andrew Jones—turned to a common laboratory method: splicing DNA.
After isolating the DNA sequence behind the production of psilocybin in mushrooms, the team did a simple copy/paste, splicing the mushroom DNA into the genome of E. coli. Then, they sat back and watched the E. coli work its mushroom magic, following the DNA’s instructions to produce psilocybin.
Scientists Are Working Technology to Mass Produce Psilocybin
“Once we transferred the DNA, we saw a tiny peak emerge in our data,” said Alexandra Adams, a junior chemical engineering major and lead author of the study presenting the groundbreaking work. “We knew we had done something huge.”
And something out of a sci-fi novel, too. By imbuing the humble E. coli bacterium with the psilocybin-producing power of a fungus, the researchers made the jump between two completely distinct domains of life. They may also have developed a method for producing psilocybin that overcomes the natural limitations of cultivating mushrooms and the exorbitant expense of synthetic chemical production methods.
Genetically engineering E. coli to make psilocybin was only half of the puzzle, however. The other half was figuring out how to kick the E. coli into overdrive so that it didn’t just produce psilocybin, but produced a ton of it. That took several months of experimenting, and the team is still tweaking the setup to find the optimal conditions for E. coli to produce the compound.
How optimal? The newly-published study, which appears in Metabolic Engineering, says the experiments are now yielding gram-scale production—1.16 grams per liter, to be exact. “Over the course of this study we improved production from only a few milligrams per liter to over a gram per liter, a near 500-fold increase,” said Jones. With that kind of speed and scale it’s possible to conceive of a future with legal and economically mass-produced psilocybin.
Chemical Engineers Eyeing Future for Psilocybin-based Medicines
Psychedelic mushrooms, plants, and cacti, or more specifically, the compounds in them—DMT, psilocybin, mescaline—are gaining increasing recognition and legitimacy as therapeutic, medicinal substances. There are currently a number of clinical trials underway to investigate the potential use for psychedelic compounds in the treatment of addiction, depression, post-traumatic stress disorder and other mental health conditions. Recent studies have shown how therapeutic doses of psychedelic substances can heal and regenerate brain tissue and help treat mental illness. Other studies show how psychedelics can help with wean people off of highly addictive drugs.
Researchers are likewise turning their attention to the ways psychedelic experiences expand consciousness and improve mental health. Indeed, the use of psychedelics dates back millennia, and they have been central to the spiritual and healing practices of many cultures. Now that more medical professionals are beginning to take psychedelics seriously, chemical engineers and research scientists are getting to work unlocking their vast potential for human health and wellness.
Researchers At Miami University Produce Psilocybin From E. coli Bacteria was posted on High Times.
Original Post: High Times: Florida Congressman Wants To Downgrade Controlled Substance Scheduling For Marijuana
[Canniseur: Introducing a simple bill to move cannabis from Schedule 1 to Schedule 3 makes so much sense. This bill, containing only this rescheduling, comes at a time when our country could use a little relief from all the hate. Call your Senator or Congress representatives and let them know you support the Marijuana 1-to-3 Act of 2019.]
The lawmaker is aiming to reschedule cannabis from a Schedule I to a Schedule III controlled substance.
On Thursday, Congressman Greg Steube, who represents Florida’s 17th district, introduced a bill that would downgrade the controlled substance scheduling for marijuana. Steube’s bill, the Marijuana 1-to-3 Act of 2019, would reclassify cannabis as a Schedule III controlled substance. Currently, the federal government considers cannabis a Schedule I drug with “no currently accepted medical use and a high potential for abuse.” Downgrading cannabis to Schedule III, a classification which includes drugs like ketamine and anabolic steroids, would primarily make it easier for scientists to research cannabis and its health effects.
Marijuana 1-to-3 Act Would Allow for Federally-Funded Cannabis Research
On September 12, Congressman Greg Steube tweeted a press release announcing a bill to downgrade marijuana from a Schedule I to a Schedule III controlled substance. “The Marijuana 1-to-3 Act will allow additional research to be done on the benefits of marijuana by removing bureaucratic red tape,” Steube wrote in the tweet.
According to Steube’s press release, the bill directs the Attorney General of the United States to make a simple change to the Controlled Substances Act: dropping “marihuana” down to Schedule III. In the release, Steube acknowledges there are clearly medical benefits to cannabis. “We hear every day about the positive health benefits of marijuana,” Steube said. “Whether it’s young children with seizure disorders, or veterans suffering from chronic pain.”
Federal research into the health effects of cannabis has been extremely restricted due to its Schedule I status. A Schedule III designation would remove many of those barriers, including one of the most substantial: funding. As a Schedule III substance, federal funds would be available to support research projects on cannabis and its medical and therapeutic applications.
Marijuana 1-to-3 Act Would Also Benefit Cannabis Industry
Congressman Steube’s Marijuana 1-to-3 Act is simple. Unlike another rescheduling bill also filed Thursday by a bipartisan pair of Florida Representatives, which would require federal agencies to develop research programs and designate “Centers of Excellence in Cannabis Research,” Steube’s bill just directs the U.S. Attorney General to reschedule marijuana.
Still, Steube believes the reclassification is enough to drastically expand opportunities for research and study into the medical and recreational uses of cannabis. “With this rescheduling, researchers can now access federal funds to research this substance and determine its medical value,” Steube said.
But the rescheduling of cannabis won’t just impact research scientists’ eagerness to study it. It could also have a major impact on the legal cannabis industry. Many of the financial problems facing the industry, like its difficulty accessing bank services and inability to obtain tax deductions and other subsidies, stem from companies’ trafficking in what the federal government considers a Schedule I drug. If marijuana were to be rescheduled down to level III, cannabis businesses would become eligible for a number of federal tax deductions.
The Marijuana 1-to-3 Act isn’t the first piece of federal cannabis legislation Congressman Steube has introduced. Back in April, Rep. Steube, a former Army JAG Officer, put forward a bill to protect U.S. veterans who use medically prescribed cannabis from losing their VA benefits.
In 2017, the VA adopted a directive that protects veterans from losing their benefits over lawful medical cannabis use and authorizes VA officials to discuss cannabis treatments with patients. Steube’s bill aims to make that directive law, making sure no future administrative changes put veterans at risk of losing their benefits. “As a veteran, I’m committed to ensuring that veterans receive the care they deserve, and I know that sometimes that care can include medical marijuana,” Steube said.
Florida Congressman Wants To Downgrade Controlled Substance Scheduling For Marijuana was posted on High Times.
Original Post: High Times: Thai Lawmakers Reportedly Pushing for Medical Marijuana Research
[Canniseur: Thailand is embracing its long history of cannabis as medicine. By enabling all Thai citizens to grow and sell cannabis for medical purposes, they are dissuading big business from taking over the market.]
After becoming the first Southeast Asian nation to legalize medical cannabis, Thailand is moving swiftly to build its medical cannabis industry.
In Thailand, there is a long cultural tradition of using cannabis for medicinal and therapeutic purposes. Like many of its neighboring countries in Southeast Asia, however, Thailand has historically imposed harsh anti-drug laws that strongly penalize cannabis cultivation and use. But late last year, the nation of nearly 70 million people became the first in the region to legalize medical cannabis. And now, Thai lawmakers are pushing to develop policies aimed at creating a robust medical cannabis industry.
In a policy document released July 21 ahead of a key national assembly debate set for Thursday, Thai leaders call for accelerating research and developing technologies to bring marijuana, hemp and other medicinal herbs into the country’s medical industry. The policy document also sets out the unique goal of enabling all Thai citizens to grow and sell cannabis for medical purposes.
Thai Lawmakers Propose Policies to Jumpstart Medical Marijuana Industry
In March 2019, Thailand held its first election since the 2014 military coup d’état that installed coup leader General Prayuth Chan-ocha as prime minster. Following the controversial March elections, Prayuth held on to power to head up Thailand’s civilian government with a ruling coalition of 19 parties. One of the largest parties of that coalition, the Bhumjaithai Party, made developing Thailand’s medical cannabis industry a central part of its agenda. And since the election, the party has been demanding policy action from Thai lawmakers and the prime minister.
One of the leading voices pushing to make medical marijuana a part of the government’s agenda is Bhumjaithai party leader Anutin Charnvirakul. Charnvirakul serves as deputy prime minster and health minister. And in statements to Thai media, Charnvirakul has called for changes to the banned drugs list and new rules to make it easier for hospitals to prescribe drugs containing CBD and THC.
The health minister has also called for highly permissive cultivation laws that would permit all Thais to grow and produce medical cannabis to make money. All of those demands are part of a policy document Reuters obtained Sunday. “The study and technological development of marijuana, hemp and other medicinal herbs should be sped up for the medical industry to create economic opportunity and income for the people,” the policy document said.
Policy Shift Could Position Thailand as Major Regional Cannabis Supplier
Support for a legal medical marijuana industry is widespread across Thailand and backed by the ruling military government. Late last year, the military-appointed National Legislative Assembly approved medical marijuana legalization with a vote of 166 to 0 (13 abstaining). After the vote, the lawmaker in charge of drafting the medical marijuana bill called its passage “a New Year’s gift from the National Legislative Assembly to the government and the Thai people.”
Indeed, economic analysts predict a medical marijuana industry in Thailand could be a gift to the whole region. According to Bloomberg, the forecast for the legal cannabis market in Asia is expected to grow to $8.5 billion over the next five years. Those projections are prompting some in Prime Minister Prayuth’s coalition to push for full recreational legalization. It’s a move that has the support of deputy prime minister and health minister Charnvirakul, whose positions in government make it easy for him to change regulations and laws surrounding cannabis cultivation and patient access.
The Thai government is also taking steps to prevent its nascent industry from being overtaken by international cannabis conglomerates. Sopon Mekthon, who heads Thailand’s medical cannabis research efforts with the Government Pharmaceutical Organization, said “we want to be a leader in marijuana. And we have traditional Thai medicine knowledge that’s over 300 years old.”
Thai Lawmakers Reportedly Pushing for Medical Marijuana Research was posted on High Times.
Original Post: High Times: Prosecutor Issues Warning About Cannabis Edibles That Look Like Normal Candy
[Canniseur: Parents and children shouldn’t have to look closely at packaging to figure out if it’s a THC infused edible or not. This is a dangerous. The packaging needs to be distinct and unique from the original packaging. By making packaging look like regular candy, the manufacturer of this candy risks having more packaging rules and regulations in a marketplace that already has too many rules and regulations.]
After police intercepted a package of cannabis edibles in Kentucky, U.S. Attorney Mike Stuart said Trick or Treat will never be the same.
Halloween is still months away. But in Charleston, West Virginia, U.S. Attorney Mike Stuart says Trick or Treat will never be the same. On Thursday, Stuart’s office in the Southern District of West Virginia issued a public health alert about THC-infused edibles. The alert warns about cannabis edibles that look like normal candy, saying they pose a potential hazard to kids. The alert stems from a June 15 drug interdiction that intercepted 7.5 pounds of cannabis-infused candy traveling through Kentucky. The statement issued by the prosecutor’s office provides an image comparing the intercepted edibles to the popular Nerds Rope candy.
US Attorney Says THC Candy is “All Trick and No Treat”
United States Attorney Mike Stuart is warning the West Virginia public that THC-infused edibles are being packaged in a manner that is appealing to kids. The public health alert comes just days after members of an Appalachia High Intensity Drug Trafficking Area (AHIDTA) task force intercepted a parcel containing several pounds of marijuana edibles. In a bulletin announcing the seizure, AHIDTA stated that the parcel had originated in Mill Valley, California and was on its way to Coconut Creek, Florida when the task force intercepted it in Kentucky.
Courtesy of The Justice Department
The edibles in question closely resemble the brand packaging of normal Nerds Rope candy. But the AHIDTA bulletin acknowledges that the THC-infused candy had clear warnings to keep out of the reach of children and animals. The packages also display California’s THC warning badge and large lettering indicating the quantity of THC in the package—400 mg per rope. Above the word Nerds on the cannabis-infused version, block letters spell out “Medical.”
Despite these warnings and labels, however, the HIDTA bulletin says the edibles’ packaging uses colors, shapes and promotional characters that make them appear similar to the commercial version of the candy. The bulletin then cites a 2016 University of Washington study on the factors that attract children to edibles packages. The research details that the colors red, orange, yellow and green were most attractive to children. The THC-infused Nerds Rope packages contained all those colors, as well as “festive writing” and common naming conventions. The result, HIDTA says, is a product that is highly appealing to children and youths.
“This fake ‘candy’ is all trick and no treat,” said U.S. Attorney Mike Stuart. “It is packaged like candy. It looks like popular candy, tastes like candy. But, instead, it is a very powerful and potent way to get high.”
Parents Urged to Inspect All Candy for THC
“High-potency” edibles are increasingly coming under attack by law enforcement and public health officials for the perceived threat they pose to young people. U.S. Attorney Stuart’s public health alert hits familiar notes. “Any unsuspecting child or teenager could easily stumble along a package and innocently et it not realizing the potency of the THC infused in the product,” Stuart’s office said in the alert. “The average marijuana joint contains 0.3 grams of THC. This fake “candy” contains nearly 35 percent more THC than an entire average joint. It is outrageous that this powerful drug is marketed to children,” the statement continues. But states that have legalized retail cannabis products like edibles all have regulations that prohibit packages children might find appealing.
But some of the traits of the intercepted edibles suggest they were manufactured before California revised its rules for marijuana packaging. When those regulations took effect, they instructed retailers to destroy non-compliant products. But instead of the incinerator, many products ended up on illicit distribution networks. It’s therefore possible that so-called black market diversion sent these “Medical” Nerds Ropes with THC on their way to Florida.
So states are trying to do something about THC products that could appeal to children. But U.S. attorney Stuart’s office says parents will have to pick up the slack. “Parenting is challenge enough without having to check a child’s candy for potent levels of THC. This just means parents will have to work double duty on Halloween.”
Prosecutor Issues Warning About Cannabis Edibles That Look Like Normal Candy was posted on High Times.